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KMID : 1144820210270040264
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대한의생명과학회지
2021 Volume.27 No. 4 p.264 ~ p.269
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Efficacy of Disinfectants against Health-Associated Multi-drug Resistant Clinical Isolates
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An Jeong-Lib
Kim Sang-Ha
Yu Young-Bin
Kim Sung-Hyun
Lee Moo-Sik
Kim Young-Kwon
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Abstract
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The purpose of this study was to evaluate the disinfecting efficacy of peracetic acid (PAA), sodium hypochlorite (NaOCl) and phenol, which are representative disinfectants in medical environments using four types of multi-drug resistance (MDR) clinical isolates with healthcare-associated infections (HAI). 26 antibiotic susceptibility tests were conducted for the four types of MDR clinical isolates in the same way as for clinical specimens. The minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) of the disinfectants were determined by using in vitro liquid medium dilution method and inoculation of the plate medium. Both the MIC and MBC of phenol against MRSA and VRE were 3.1%, while those against KPC and MRPA were 6.2%. The MIC and MBC of peracetic acid (PAA) against MRSA, VRE, KPC, and MRPA were 0.18%. The MIC and MBC of sodium hypochlorite (NaOCl) against MRSA were 0.39% and 0.78%, respectively. Both values of MIC and MBC were 0.78% for VRE. In addition, KPC and MRPA showed 0.39% for MIC and 0.78% for MBC. For all MDR strains used in this study, sodium hypochlorite and peracetic acid showed significant sterilizing efficiency, while no clear correlation was identified between antibiotic resistance clinical isolated and ability of disinfection.
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KEYWORD
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Minimum Inhibition Concentration (MIC), Multi-drug Resistance clinical isolates, Peracetic acid (PAA), Phenol, Sodium hypochlorite
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